drug distribution in the body
Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes. Drug distribution in the body RATE OF DISTRIBUTION Factors influencing the rate of distribution The rate of distribution of a drug between the blood and a tissue can be limited either by perfusion or by diffusion. A perfusion-rate limitation prevails when the tissue membranes present no barrier to distribution. 1 Drugs and the Body Pharmacokinetics - The study of the movement of drugs through the body. After a drug is absorbed into the bloodstream, it rapidly circulates through the body; the average circulation time of blood is 1 minute. Once the drug is administered, the Phamacokinetic phase or absorption begins. Vd = volume of distribution D = dose Cp = plasma level k = kg body weight ; Drugs with high Vd are not present in the blood to any extent and it follows, therefore, that tests on blood specimens may give an inaccurate picture of total body burden of the drug. In addition to protein availability, other factors may affect drug absorption and distribution in the body as a whole or at specific sites within the body. In the bloodstream, drugs are transported partly in solution as free (unbound) drug and partly reversibly bound to blood Distribution of drugs can be defined as: The process by which a drug reversibly leaves the blood stream and enters the interstitium (extracellular fluid) and/or the cells or tissues.. Pharmacokinetics is the way the body acts on the drug once it is administered. Pharmacokinetics is the way the body acts on the drug once it is administered. After a drug enters the systemic circulation, it is distributed to the bodys tissues. The four processes involved are absorption, distribution, metabolism and Drug distribution refers to the movement of drug to and from the blood and various tissues of the body (for example, fat, muscle, and brain tissue) and the relative proportions of drug in the tissues. This parameter measures the relative distribution of drugs between tissue and plasma and depends on the plasma and The four processes involved are absorption, distribution, metabolism and The four processes involved when a drug is taken are absorption, distribution, metabolism and elimination or excretion (ADME). The following table highlights some of these other factors. It is the measure of the rate (kinetics) of absorption, distribution, metabolism and excretion (ADME). Constant, uniform concentration achieved. Drug Absorption, Distribution and Metabolism. The movement of drug molecules in the body in relation to the drug's absorption, distribution, metabolism, and excretion. Studying pharmacokinetics during drug development 8 ... Summary Pharmacokinetics describes the absorption of drugs into the body and their distribution The distribution of most drugs in the body is far from even. In addition to protein availability, other factors may affect drug absorption and distribution in the body as a whole or at specific sites within the body. Get this from a library! The extent of drug distribution into tissues depends on the degree of plasma protein and tissue binding. After a drug enters the systemic circulation, it is distributed to the bodys tissues. ... what process in the body contributes to the drug's prescence in the body for several ... What factors affect distribution? Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids. In pharmacokinetics, the distribution is described by the parameter V, the apparent volume of distribution. Partition coefficient of a drug between the plasma and the rest of the body.